08:00
08:30
Opening Ceremony
Prof. José Paulo MOTA
UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal
Auditorium II & Overflow Auditorium III
Session 1: Modeling and Theory
Auditorium II & Overflow Auditorium III
08:40
Introduction by session chair
Prof. Massimo MORBIDELLI
POLITECNICO MILANO, Milano, Italy
Massimo Morbidelli received his Laurea in Chemical Engineering at the Politecnico di Milano and PhD at the University of Notre Dame. He is currently Professor at the Politecnico di Milano (Italy) and Professor Emeritus at the ETH Zurich (Switzerland).
His main research interest is in the area of biopharmaceutics and specifically on the integrated continuous manufacturing of therapeutic proteins, and its automation and digitalization.
Massimo Morbidelli is co-author of more than 750 papers, 23 international patents and six books, including the very recent ones on Continuous Biopharmaceutical Processes (2018), Cambridge University Press, coauthored with D Pfister and L Nicoud and Perfusion Cell Culture Processes for Biopharmaceuticals (2020), Cambridge University Press, coauthored with M Wolf and J-M Bielser. He is the first chemical engineer elected to the Italian Academy of Science (Accademia dei Lincei), serves as the Executive Editor of the ACS journal of Industrial & Engineering Chemistry Research, and is the recipient of:
- R.H. Wilhelm Award in Chemical Reaction Engineering by the American Institute of Chemical Engineers, 2005
- Gerhard Damköhler-Medaille of DECHEMA.and VDI-GVC, 2014
- Excellence in Process Development Research Award by the American Institute of Chemical Engineers, 2017
- Separations Science and Technology Award by the American Chemical Society, 2018
- ICB Award, Contributions to Integrated Continuous Biomanufacturing, 2019
- Laurea Honoris Causa, Slovak University of Technology, Bratislava, 2019
In his career he advised more than 100 PhD students. He is a cofounder of ChromaCon Ltd., a spin-off company from his research group, which brings new chromatographic processes (MCSGP-technology) for the purification of proteins and peptides to the market (now acquired by YMC, Japan) and of DataHow Ltd. for the application of data science and machine learning in Biotechnology and specifically in the Biopharma Industry.
08:45
Measurement of Separation Materials to Enable Mechanistic Modelling and Rational Design (KL01)
Prof. Dan BRACEWELL
UNIVERSITY COLLEGE LONDON, London, United Kingdom
Daniel G. Bracewell is Professor of Bioprocess Analysis at the UCL Department of Biochemical Engineering. He has made major contributions to the fundamental understanding of biopharmaceutical purification operations, including collaborations with Thailand, India and the USA. He has authored more than 90 peer reviewed journal articles in the area to date and currently supervises 15 doctoral and postdoctoral projects, many of these studies are in collaboration with industry. One such project was the basis from which the spinout Puridify a nanofibre absorption technology company was created. He is academic lead for the UCL-Pall Biotech Centre of Excellence.
09:25
Models in the SMB and SMBR Process Development (IL01)
Dr Damien LEINEKUGEL LE COCQ
IFP ENERGIES NOUVELLES, Solaize, France
Damien Leinekugel-le-Cocq works at the Process Design and Modeling Division, IFP Energies Nouvelles. He was graduated in chemistry (CPE Lyon, 2001) and he received his Ph.D. in Chemical Engineering from Lyon 1 University in 2004. He has 15 years of experience in separation process development in Refining, Petro Chemistry and Green Chemistry. Particular focus is on chromatographic, adsorption and reaction coupling separation processes. He has contributed to numerous technology development for Eluxyl process (production of paraxylene by Simulated Moving Bed).
09:50
Development of Preparative Chromatographic Processes for the Classification of Nanoparticles (OC01)
Prof. Malte KASPEREIT
FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany
Malte Kaspereit studied Process Engineering a Technical University of Clausthal, Germany. He spent 11 years as researcher and PostDoc at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, Germany. He obtained his PhD from Otto von Guericke University in Magdeburg under supervision of Andreas Seidel-Morgenstern. In 2011 he became professor at the Institute for Separation Science & Technology, Friedrich-Alexander-University in Erlangen, Germany.
MK leads the Advanced Separation Processes group at the Institute. The group develops efficient processes for challenging separations in the production of bulk and fine chemicals, pharmaceuticals, and biological products. MK is member of the SPICA scientific committee.
10:10
Optimizing AAV Full/Empty Separation Using Mechanistic Modeling (OC02)
Dr Tatjana TRUNZER
CYTIVA, Karlsruhe, Germany
Tatjana is a scientist in the field of mechanistic modeling, researching and developing the GoSilico™ Chromatography Modeling Software at Cytiva. She has extensive background with in vitro and in silico chromatography process development, flow-through operations and scaling. She has studied for a Bachelor and Master of Sciences in Chemical Engineering, and a Dr.-Ing. in biopharmaceutical process development. Tatjana enjoys bringing novel in silico tools to the industry, and searching for an improved understanding of the mechanistic behavior of bioprocessing, enabling rapid process development.
10:30
Coffee break & Exhibiton
Ground floor
Session 2: Biomolecules I
Auditorium II & Overflow Auditorium III
11:00
Introduction by session chair
Prof. Andreas SEIDEL-MORGENSTERN
MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany
11:05
Proteins at Chromatographic Surfaces – Competitive Binding and On-column Aggregate Formation on Monomodal and Multimodal Anion Exchangers (KL02)
Prof. Giorgio CARTA
UNIVERSITY OF VIRGINIA, Charlottesville, United States
Giorgio Carta received his PhD in Chemical Engineering from the University of Delaware in 1984 and is currently the Lawrence R. Quarles Professor in the Department of Chemical Engineering at the University of Virginia. He has published extensively in the area of adsorption and ion exchange with emphasis on protein chromatography. He has co-authored the book “Protein Chromatography – Process Development and Scale-Up," Wiley-VCH, 1st ed. 2010, 2nd ed. 2020, has served as section co-editor of Section 16 “Adsorption and Ion Exchange” of Perry's Chemical Engineers' Handbook, 7th, 8th, and 9th edition, and authored the textbook "Heat and Mass Transfer for Chemical Engineers: Principles and Applications," McGraw-Hill, 2021. He has served as member of the Organizing Committee of PREP International Symposium, Exhibit & Workshops on Preparative and Process Chromatography since 1997 and as Chair of the PREP Symposium annually since 2009. He is also involved extensively in professional education in the field of protein chromatography, including leading a short course in protein chromatography held twice a year at the University of Virginia. Giorgio Carta is an Editor of Biotechnology Journal and a member of the Editorial Board of Separation Science & Technology. He is a consultant for a number of chemical and pharmaceutical companies.
11:45
Protein Purification Using Magnetic Adsorbents and Magnetic Separation - a Robust Alternative to Conventional Chromatography? (IL02)
Prof. Mathias FRANZREB
KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany
Matthias Franzreb (°1963) received a Ph.D. in chemical engineering from the University of Karlsruhe. During his Ph.D. focussing on ion exchange technology, he worked partly at PennState University, State College, USA under the supervision of Prof. Fred Helfferich. Afterwards he entered the Karlsruhe Institute of Technology and started his work on magnetic micro-adsorbents and their combination with technical scale magnetic separation. In 2002, he finished his Habilitation and in 2009, he was awarded an Extraordinary Professorship by the Karlsruhe Institute of Technology (KIT). Since 2014, he is Associate Director of the Institute of Functional Interfaces at the KIT. His research focuses on novel bioseparation techniques based on physical stimuli (magnetic, electrostatic, and thermal) as well as bioprocess modelling.
12:10
Intensified Purification of Monoclonal Antibodies with Double Flow-Through Membrane Chromatography (OC03)
Mr Fabian SCHMITZ
SARTORIUS STEDIM BIOTECH GMBH, Göttingen, Germany
Fabian Schmitz studied Pharmaceutical Bioprocess Engineering at the Technical University of Munich, Germany. He spent almost 3 years as a process application engineer for downstream processing at the department Integrated Solutions of Sartorius in Guxhagen, Germany. In the beginning of 2020 he became a scientist and PhD student in the Downstream Processing group of the Advanced BioProcessing department in Corporate Research of Sartorius in Göttingen, Germany. FS is doing his PhD in the field of intensified and continuous downstream processes of biopharmaceuticals under the supervision of Mirjana Minceva at the Technical University of Munich in Germany.
12:30
Coupling Preferential Precipitation and IEX for Reducing Acidic Variant Content in Monoclonal Antibody Pools (OC04)
Prof. Dorota ANTOS
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
Dorota Antos received a Ph.D. in chemical engineering from Technical University of Wroclaw, Poland. The Ph.D. thesis was awarded by Polish Minister of Education.
She completed internships at Politecnico di Milano, Italy, at Max-Planck-Institute in Magdeburg, Germany, and in the frame of Fulbright Grant, at University of Virginia, USA.
She habilitated in the field of chromatography and adsorption at Otto-von-Guericke Universitaet in Magdeburg, Germany.
In 2012 she was nominated by Polish President as a full professor.
Since 2014 she is a chair of Department of Chemical Engineering and Processing, Faculty of Chemistry, of Rzeszow University of Technology, Rzeszow. Since 2016 she is a dean of Faculty of Chemistry.
12:50
Lunch break & Exhibition until 14:05
Ground floor
13:00
13:00
Nouryon / Kromasil Seminar
Chromatographic toolbox for Purification of GLP-1 Agonist and Advances in the Development of Stationary Phases and Purifications in Preparative Chromatography
13:00
Osaka Soda Co., Ltd. Seminar
You need a COMPASS!
13:00
Sartorius Seminar
Chromatography challenges to purify Oligonucleotides and mRNA: how to deal with aggressive buffer and high temperature?
Session 3: Biomolecules II
Auditorium II & Overflow Auditorium III
14:05
Introduction by session chair
Dr Michael SCHULTE
MERCK KGAA, Darmstadt, Germany
14:10
Process Scale MCSGP Purification of large Synthetic Molecules (KL03)
Dr Ralf EISENHUTH
BACHEM, Bubendorf, Switzerland
With a Ph. D. in organic chemistry from the University of Karlsruhe (KIT), Dr. Ralf Eisenhuth joined Bachem AG in 2008. Over the last decade, he held several positions at Bachem; ranging from process development to leading the large-scale purification of peptides at the Bubendorf site. In his current position as Process Manager Chromatography and Technology Transfer, he is focusing on innovative purification technologies and processes.
14:50
Making Affinity Chromatography an Integral Part of Vaccine Development and Manufacturing (IL03)
Dr Mikkel NISSUM
GSK, Siena, Italy
Mikkel is currently CMC Quality Head Italy at GSK vaccines leading the strategic quality support to vaccine development projects. Prior to this role, Mikkel was leading research and technical development of vaccine projects from pre-clinical until commercial launch. Mikkel was trained as analytical chemist and biochemist at the University of Southern Denmark, then moved to the University of Wurzburg as researcher in optical spectroscopy. Before joining GSK Vaccines in 2009, Mikkel worked in a number of biotech and medical technology companies as senior scientist and laboratory head including Becton Dickinson, Hamilton, Tecan and MWG-Biotech.
15:15
Integration of Chromatography and Allied Separation Technologies Towards Autonomous Continuous MRNA Production (OC05)
Dr Axel SCHMIDT
INSTITUT FÜR THERMISCHE VERFAHRENSTECHNIK, TUC, Clausthal-Zellerfeld, Germany
Axel Schmidt (Dr.-Ing. In Process Engineering) is a Habilitand at the Institute for Separation and Process Technology at Clausthal University of Technology and has developed his PhD-Thesis on the topic of “Process integration using validated digital twins of liquid-liquid extraction processes for the recovery of metallic, botanical and biotechnological value components “ from October 2015 to the end of 2020 at Clausthal University of Technology at the Institute for Separation and Process Technology.
He lectures on Biotechnology as well as Separation Technology and Process Modeling. Mr. Schmidt operates and supervises the laboratory and pilot plant extraction equipment up to 1-2 l/h, i.e. a settler160 l hold-up piloting for cell separation and capture after cultivation at the institute.
At the institute Mr. Schmidt developed and established an industrial level extraction process development strategy and continuous processing for biologics and botanicals.
His research focuses on process development, integration, intensification, modeling and simulation with a focus on chromatography, distillation, liquid-liquid / solid-liquid extraction, precipitation, crystallization as well as filtration technologies. He is, at the moment, the coworker who has helped to acquire the most project money for the institute from industrial and national grant institutions.
His research aims to a methodological answer of upcoming FDA demands on meeting upscale requirements as well as batch or continuous manufacturing process options for biologicals and botanicals with innovative downstream concepts reducing COG significantly.
15:35
Continuous Purification of Virus-Based Biologics Using Periodic Counter-Current Chromatography (OC06)
Dr Ricardo SILVA
IBET, Oeiras, Portugal
I joined iBET in 2014 as a Senior Scientist in the Animal Cell Technology Unit (Downstream
process development Lab). In 2019, I also integrated the Late-Stage Research and
Development unit. Before joining iBET, I completed my PhD in Chemical and Biochemical
Engineering with a specialization in numerical process simulation and optimization at Nova
University of Lisbon (2014). My studies focused on the development of continuous
countercurrent chromatography processes for petrochemical and small molecule
applications.
Currently, I am focusing on process integration/intensification (up and downstream) and
purification of recombinant proteins, cell-based products, extracellular vesicles and virusbased biologics.
ORCID iD: https://orcid.org/0000-0003-2959-102X
Email: rsilva@ibet.pt
Linkedin: www.linkedin.com/in/rjs-silva
URL: www.ibet.p
15:55
Coffee break
Ground floor
Session 4: Small Molecules
Auditorium II & Overflow Auditorium III
16:25
Introduction by session chair
Dr Olivier DAPREMONT
AMPAC FINE CHEMICALS, Rancho Cordova, United States
16:30
The Evolution of Chromatographic Processes for Small Molecules Between Research and Production of APIs (KL04)
Dr Gunnar GARKE
BAYER AG, Wuppertal, Germany
Gunnar Garke is currently working as expert and laboratory manager for preparative HPLC at Bayer AG Pharmaceuticals. He is responsible for the development and upscaling of chromatographic purification processes of small molecule APIs from g to multi-kg scale. In addition Gunnar Garke is also involved in and a consultant for commercial chromatographic manufacturing. He received his Ph.D. in 2000 from the Institute of Biochemical Engineering at the Gesellschaft fuer Biotechnologische Forschung mbH in Braunschweig, Germany. After working for two years in downstream processing of proteins at IBA Biologics GmbH, he went to the Chemical Development of small molecules at Schering AG. In 2008 he moved to Bayer AG in Wuppertal in the same position.
17:10
Large Scale SFC to Enable Delivery of Candidate Drugs; Cost Savings, Sustainability and Fundamental Learnings (IL04)
Dr Hanna LEEK
ASTRAZENECA R&D, Mölndal, Sweden
Hanna Leek
With a background in chemical engineering Hanna joined AstraZeneca in 1998. During her career, she has been one of the key players in introducing preparative chromatography to the site in Gothenburg and in the buildup of a large-scale separation laboratory. Hanna has over the past 15 years been driving the introduction of SFC which is today the main purification technique used at the site.
Currently she is working as a Director at Early Chemical Development, leading a team of separation scientists with the remit of solving both chiral and achiral separation problems, ranging from small molecules to large peptide conjugates.
17:35
Fixed-Bed and Simulated Moving Bed Chromatography Using Achiral and Chiral Adsorbents for the Complete Preparative Separation of a Quaternary Mixture (OC07)
Mr Rami ARAFAH
POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal
P.h.D. student at the University of Porto, attending the Chemical and Biological Engineering doctoral programme.
His research interest is multicomponent chiral separations and other high-added value compounds by simulated moving bed based-processes.
Current project: Complete separation of nadolol stereoisomers using preparative liquid chromatography.
17:55
High-Throughput Analytical and Purification Capabilities at Janssen Research and Development, Toledo (OC08)
Dr Alberto FONTANA
JANSSEN, Toledo, Spain
Senior experienced chemist, working 22 years at the Toledo´s Janssen Analytical & HTP team with proficiency in chromatographic techniques at both the Analytical and the Preparative lab. During these years he implemented Open-Access on the Analytical-MS systems and set up the High Throughput Purification-MS platform. Expert on method development, achieving cycle times reductions and increasing the automation on the systems. Knowledgeable on different MS software and on IT workflows with competence to request improvements to vendors or to find new solutions.
Techniques used: HPLC-MS, UHPLC-MS (LRMS and HRMS), GC-MS, SFC-MS, DSC, RP-Flash-RP, HPLC PREP-MS and HPLC-UV.
Publications: 2 (main author), 7 (coauthor); work presented at international congresses.
18:15
Poster Session 1 sponsored by Cytiva & Networking
Foyer 1st floor
19:15