SPICA 2022

18th International Symposium on Preparative and Industrial Chromatography and Allied Techniques

 Lisbon, Portugal    October 11-14, 2022

Programme


13:00

Registration

Workshops (subject to prior registration)

14:00

Start of sessions

Workshop 1
Workshop 2
Workshop 1
14:00
Continuous Chromatography for Small Molecules: Principle, Process Development and Large Scale Manufacturing
Dr Olivier DAPREMONT
AMPAC FINE CHEMICALS, Rancho Cordova, United States
Workshop 2
14:00
Introduction to Machine-Learning Methods for Process Development. From Multivariate Analysis to Hybrid Models
Dr Alessandro BUTTE
DATAHOW, Zurich, Switzerland
15:30

Coffee break

16:00

Start of sessions

Workshop 3
Workshop 4
Workshop 3
16:00
Prep Chiral and Achiral SFC: Principles and Applications
Dr Eric FRANCOTTE
FRANCOTTECONSULTING, Nuglar, Switzerland
Dr Gerard ROSSE
PIC SOLUTION, San Diego, United States
Workshop 4
16:00
Application of Machine-Learning Methods to the Production of Therapeutic Proteins
Prof. Massimo MORBIDELLI
POLITECNICO MILANO, Milano, Italy
17:45

Welcome Reception

19:00

End of the Day

08:00

Registration

08:30

Opening Ceremony

Session 1: Modeling and Theory

08:40

Introduction by session chair

08:45

Measurement of Separation Materials to Enable Mechanistic Modelling and Rational Design (KL01)

Prof. Dan BRACEWELL
UNIVERSITY COLLEGE LONDON, London, United Kingdom
09:25

Models in the SMB and SMBR Process Development (IL01)

Dr Damien LEINEKUGEL LE COCQ
IFP ENERGIES NOUVELLES, Solaize, France
09:50

Development of Preparative Chromatographic Processes for the Classification of Nanoparticles (OC01)

Prof. Malte KASPEREIT
FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany
10:10

Optimizing AAV Full/Empty Separation Using Mechanistic Modeling (OC02)

Dr Tatjana TRUNZER
CYTIVA, Karlsruhe, Germany
10:30

Coffee break & Exhibiton

Session 2: Biomolecules I

11:00

Introduction by session chair

11:05

Proteins at Chromatographic Surfaces – Competitive Binding and On-column Aggregate Formation on Monomodal and Multimodal Anion Exchangers (KL02)

Prof. Giorgio CARTA
UNIVERSITY OF VIRGINIA, Charlottesville, United States
11:45

Protein Purification Using Magnetic Adsorbents and Magnetic Separation - a Robust Alternative to Conventional Chromatography? (IL02)

Prof. Mathias FRANZREB
KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany
12:10

Intensified Purification of Monoclonal Antibodies with Double Flow-Through Membrane Chromatography (OC03)

Mr Fabian SCHMITZ
SARTORIUS STEDIM BIOTECH GMBH, Göttingen, Germany
12:30

Coupling Preferential Precipitation and IEX for Reducing Acidic Variant Content in Monoclonal Antibody Pools (OC04)

Prof. Dorota ANTOS
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
12:50

Lunch break, Exhibition & Vendor Seminars

13:00

Start of sessions

Vendor Seminar 1
Vendor Seminar 2
Vendor Seminar 3
Vendor Seminar 1
13:00
Nouryon / Kromasil Seminar
Chromatographic toolbox for Purification of GLP-1 Agonist and Advances in the Development of Stationary Phases and Purifications in Preparative Chromatography
Vendor Seminar 2
13:00
Osaka Soda Co., Ltd. Seminar
You need a COMPASS!
Vendor Seminar 3
13:00
Sartorius Seminar
Title to be announced

Session 3: Biomolecules II

14:05

Introduction by session chair

14:10

Process Scale MCSGP Purification of large Synthetic Molecules (KL03)

Dr Ralf EISENHUTH
BACHEM, Bubendorf, Switzerland
14:50

Making Affinity Chromatography an Integral Part of Vaccine Development and Manufacturing (IL03)

Dr Mikkel NISSUM
GSK, Siena, Italy
15:15

Integration of Chromatography and Allied Separation Technologies Towards Autonomous Continuous MRNA Production (OC05)

Dr Axel SCHMIDT
INSTITUT FÜR THERMISCHE VERFAHRENSTECHNIK, TUC, Clausthal-Zellerfeld, Germany
15:35

Continuous Purification of Virus-Based Biologics Using Periodic Counter-Current Chromatography (OC06)

Dr Ricardo SILVA
IBET, Oeiras, Portugal
15:55

Coffee break

Session 4: Small Molecules

16:25

Introduction by session chair

16:30

The Evolution of Chromatographic Processes for Small Molecules Between Research and Production of APIs (KL04)

Dr Gunnar GARKE
BAYER AG, Wuppertal, Germany
17:10

Large Scale SFC to Enable Delivery of Candidate Drugs; Cost Savings, Sustainability and Fundamental Learnings (IL04)

Dr Hanna LEEK
ASTRAZENECA R&D, Mölndal, Sweden
17:35

Fixed-Bed and Simulated Moving Bed Chromatography Using Achiral and Chiral Adsorbents for the Complete Preparative Separation of a Quaternary Mixture (OC07)

Mr Rami ARAFAH
POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal
17:55

High-Throughput Analytical and Purification Capabilities at Janssen Research and Development, Toledo (OC08)

Dr Alberto FONTANA
JANSSEN, Toledo, Spain
18:15

Poster Session 1 & Networking

19:15

End of the Day

Session 5: Pharmaceutical Industry

08:30

Introduction by session chair

08:35

Small Molecule Chromatographic Purification in Pharmaceutical R&D and Manufacturing (KL05)

Dr Larry MILLER
AMGEN, Thousand Oaks, United States
09:15

Preparative Separation by Chromatography from Laboratory to Industrial Scale in a Pharmaceutical Environment Applied to Small Molecules (IL05)

Dr Antoni SEVERINO
UCB, Braine-l'Alleud, Belgium
09:40

New Purification Strategy of Polyether Block Copolymers by Means of Simulated Moving Bed Size Exclusion Chromatography (OC09)

Dr Pedro SÁ GOMES
BASF SE, Ludwigshafen am Rhein, Germany
10:00

New Approaches in Preparative Chromatography for Lipid Nanoparticle (LNP) Building Blocks (OC10)

Dr Markus JUZA
CORDEN PHARMA SWITZERLAND, Liestal, Switzerland
10:20

Coffee break & Exhibition

Session 6: Automation and Simulation

10:50

Introduction by session chair

10:55

Automation and Digitalization in the Manufacturing of Therapeutic Proteins (KL06)

Prof. Massimo MORBIDELLI
POLITECNICO MILANO, Milano, Italy
11:35

Strategies and Emerging Technologies for Downstream Purification (IL06)

Dr Gunnar MALMQUIST
CYTIVA, Uppsala, Sweden
12:00

General Bio-Chromatographic Digital Twin in Quality-By-Design Based Process Design and Machine-Learning Based Process Control (OC11)

Mr Florian VETTER
TU CLAUSTHAL, Clausthal-Zellerfeld, Germany
12:20

Hybrid Models for the Simulation and Prediction of Chromatographic Processes (OC12)

Dr Alessandro BUTTE
DATAHOW, Zurich, Switzerland
12:40

Lunch break, Exhibition & Vendor Seminars

12:50

Start of sessions

Vendor Seminar 4
Vendor Seminar 5
Vendor Seminar 6
Vendor Seminar 4
12:50
Tosoh Bioscience Seminar
Multi-column chromatography – A powerful tool to enhance productivity in downstream processing
Vendor Seminar 5
12:50
RotaChrom Technologies LLC Seminar
CPC Simulator – Accelerating Method Development in Centrifugal Partition Chromatography
Vendor Seminar 6
12:50
De Dietrich & Thar Process Seminar
Title to be announced

Session 7: Continuous Chromatography

13:55

Introduction by session chair

14:00

Cyclic Adsorption Processes. What else? (KL07)

Prof. Alirio RODRIGUES
UNIVERSITY OF PORTO, Porto, Portugal
14:40

Chromatography in Colour – Application of Processes Chromatography to the Efficient Recycling of Critical Metals (IL07)

Dr Paul O'SHAUGHNESSY
JOHNSON MATTHEY, Oxfordshire, United Kingdom
15:05

Continuous Size Fractionation of Nanoparticles for Biomedical Purposes Using Magnetic Field Controlled SMB (OC13)

Ms Laura KUGER
KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), Eggenstein-Leopoldshafen, Germany
15:25

Simulated Moving Bed Chromatography - Mass Spectrometry (SMB-MS): Continuous On-Line Sample Preparation for Process Analytical Technology (OC14)

Ms Juliane DIEHM
KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany
15:45

Coffee break

Session 8: Optimization & Prediction

16:15

Introduction by session chair

16:20

What is the Right Level of Purity? Benefits of Overpurifying and Underpurifying in Chromatography (KL08)

Prof. Tuomo SAINIO
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland
17:00

Exploring Enhanced Selectivity of Mixed Mode Cation Exchange Resins in Bispecific and Complex Immunoglobulin Purification (IL08)

Mr Wolfgang KOEHNLEIN
F. HOFFMANN-LA ROCHE, Penzberg, Germany
17:25

Short-Cut Design of Four-Zone Simulated Moving Bed Chromatography for Multi-Component Systems: Langmuir-Type Isotherms (OC15)

Dr Ju Weon LEE
OTTO VON GUERICKE UNIVERSITY, Magdeburg, Germany
17:45

Robustness Analysis by Predictive Distribution for Various Operating Configurations for Simulated Moving Bed Chromatography (OC16)

Mr Kensuke SUZUKI
NAGOYA UNIVERSITY, Nagoya, Japan
18:05

Poster session 2 & Networking

19:15

End of the Day

20:30

Gala dinner at Monte Mar Restaurant
(subject to prior registration)

Session 9: SFC & Natural Products

08:30

Introduction by session chair

08:35

The Role of CO2 Separation (SFC) in the Eco-Sustainable Production of APIs and Hemp Ingredients (IL09)

Dr Gerard ROSSE
PIC SOLUTION, San Diego, United States
09:00

The Thar Process Journey Regarding Green Chemistry Application Using Supercritical Carbon Dioxide (IL10)

Dr Lalit CHORDIA
THAR PROCESS INC., Pittsburgh, United States
09:25

Industral Application of Supercritical Fluid Simulated Moving Bed in the Separation of N-3 Pufa from Fish Oil (OC17)

Ms Xiaoqing BAO
JOPE TECHNOLOGY CO., LTD , Kaohsiung, Taiwan
09:45

Process Stabilization by Online Monitoring of a Mini-Plant Coupling Enantioselective SMB Chromatography and Enzymatic Racemization (OC18)

Ms Isabel HARRIEHAUSEN
MAX-PLANCK-INSTITUTE, Magdeburg, Germany
10:05

Study of Liquid-Liquid Chromatography Operation in the Nonlinear Range of the Partition Equilibria (OC19)

Mrs Melanie GERIGK
TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany
10:35

Coffee break

Session 10: Biomolecules III

11:05

Introduction by session chair

11:10

Progress and Trends of Virus Based Biopharmaceuticals Purification (IL11)

Prof. Cristina PEIXOTO
IBET, Oeiras, Portugal
11:35

Antimicrobial Peptide Bioproduction and Engineering for Biomedical Applications (IL12)

Prof. Susanna LEONG
SINGAPORE INSTITUTE OF TECHNOLOGY, Singapore, Singapore
12:00

Advanced Gradient SMBC Applied to Antibody Purification (OC20)

Mr Masahiro OGINO
ORGANO CORPORATION, SAGAMIHARA-shi, Japan
12:20

Design and Operation of an Integrated Continuous Downstream Process for Acid-Sensitive Mabs Based on a Calcium-Dependent Protein a Ligand (OC21)

Prof. Bernt NILSSON
LUND UNIVERSITY, Lund, Sweden
12:40

Protein Separation by Simulated Moving Bed (OC22)

Ms Albertina RIOS
UNIVERSITY OF PORTO, Porto, Portugal
13:00

Closing